The major histocompatibility complex class I (MHC-I) antigen presentation pathway is central to the adaptive immune response. In this process, intracellular proteins are degraded primarily by the ...

Activation of certain memory B cells may be driving systemic lupus erythematosus incidence in individuals who had ...

To activate T cells, DCs take up, process, and present antigens as part of major histocompatibility complexes (MHCs) that interact with T cell recep­tors. Therefore, Curtis and her team set out to ...

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity ...

Immune escape is a critical aspect of disease evolution in malignancy. The past decade has witnessed a revolution in the understanding of the complex interactions between tumor cells and host immunity ...

Therapy resistance remains a challenge with immune checkpoint inhibitors, and a new study proposes targeting ligand-dependent corepressor (LCOR) in addition to known immune targets to improve outcomes ...