Callio Therapeutics Doses First Patient in Phase I Clinical Trial of Dual-Payload ADC CLIO-8221 in Advanced HER2-Expressing Solid Tumors

Callio Therapeutics is actively developing a pipeline of promising dual-payload ADCs featuring rationally designed payload combinations for ...

Acrivon Therapeutics to Present Pre-Clinical AP3 Data at the 2026 AACR Annual Meeting Revealing Strong Synergy of ACR-368 with ADC Topo 1 Inhibitor Payloads and of both ACR-368 ...

ACR-368, a CHK1/2 inhibitor in a registrational-intent Phase 2b study, showed potent preclinical synergy with Topoisomerase 1 (Topo 1) inhibitors, commonly used payloads in antibody-drug conjugates ...

Zymeworks to Present Clinical and Preclinical Data on ADC Programs Including Novel RAS ADC Platform at AACR Annual Meeting

New clinical data from Phase 1 trial of ZW191 to be presented in an oral presentation on April 21Preclinical data highlight combination potential ...
AHA/ASA Journals

PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...
TechRadar

Could this be the key to eternal storage? Experts claim new DNA HDD can be ‘erased and overwritten repeatedly’

University of Missouri researchers claim DNA hard drives can store, erase, and rewrite repeatedly Frameshift encoding converts binary data into DNA sequences for molecular storage Nanopore sensors ...
CBS News

Investigators in Nancy Guthrie case turn to genetic genealogy for DNA leads, a tactic that's cracked big cases before

Alex Sundby is a senior editor at CBSNews.com. In addition to editing content, Alex also covers breaking news, writing about crime and severe weather as well as everything from multistate lottery ...
Frontiers

The phosphorylated tyrosine as a gatekeeper for topoisomerase catalytic activity: a molecular dynamics simulation study

DNA topoisomerase-IA is an essential enzyme that relaxes supercoiled DNA by introducing transient single-strand breaks through a covalent phosphorylated tyrosine (PTR) intermediate. This cleavage ...