DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Every human wants to live a longer life to fulfil their dream and ambitions. While modern lifestyle stresses have raised ...

Artificial intelligence is rapidly becoming medicine’s most powerful microscope, revealing patterns in human DNA that were invisible to doctors and researchers only a few years ago. Instead of ...

More than 200 metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study published in ...

Researchers have found hundreds of metabolic enzymes attached to human DNA inside the cell nucleus. Different tissues and cancers show unique patterns of these enzymes, forming a “nuclear metabolic ...

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these mutations cause serious diseases that pass down only through mothers. They ...

Thousands of previously “invisible” microproteins—tiny chains of fewer than 100 amino acids—can profoundly change human biology when mutated. A fundamental discovery is overturning decades of ...

A 19-year-old Canadian man becomes the first human cured through prime gene editing after doctors corrected a rare genetic ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature aging and embryonic lethality in mice. The findings reveal a previously ...

Scientists discovered hundreds of energy-making enzymes secretly working on human DNA—revealing a hidden “mini-metabolism” ...