Chimeric antigen receptor T cell therapy reduces vaccine immunity, with many patients lacking seroprotection despite stable antibody levels.

New York City Mayor Zohran Mamdani, girding for a potential local surge in immigration enforcement, has created an interagency group to plan for and quickly respond to such “crises.” Mamdani called ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how an innovative and stable mRNA-LNP microneedle vaccine elicits humoral and multifunctional cellular immune responses. During ...

ABSTRACT: Background: Coronavirus disease (or COVID-19), caused by the novel coronavirus SARS-CoV-2, the most virulent identified to date, remains a major global public health challenge. Given the ...

This investigator-initiated study (NCT05879419) was funded by GSK, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; #303116/2022–6 to Pasoto; #304984/2020–5 to Silva), and Fundação ...

Chronic HBV infection remains a major global health burden, with current antiviral therapies effectively suppressing viral replication but rarely achieving functional cure. Adaptive immunity is ...

In this study, we characterized the immune responses to the tattoo ink accumulating in the lymph nodes (LNs). This is very relevant as tattoo ink commonly reaches and persists in this organ in most ...

Our editorial process produces two outputs: (i) public reviews designed to be posted alongside the preprint for the benefit of readers; (ii) feedback on the manuscript for the authors, including ...

RA patients on upadacitinib and methotrexate showed robust antibody and T-cell responses to the recombinant zoster vaccine over 60 weeks. The vaccine maintained a satisfactory humoral response in 71.4 ...

Background: Infectious processes are the leading cause of pediatric consultation, and recurrent or severe infections may indicate primary immunodeficiencies (PIDs), which comprise more than 484 rare ...

Objectives Tumour necrosis factor inhibitors (TNFi) are widely used and effective as treatment for immune-mediated inflammatory diseases (IMIDs). However, TNFi therapy causes a faster waning of ...